Can reduced consumption of gonadotrophins account for ovarian compensation in unilaterally ovariectomized, immature mice injected with gonadotrophins?

Ovarian sensitivity to exogenous gonadotrophins in phenobarbital treated unilaterally ovariectomized albino rats.

Adult cycling female rats were hemispayed and administered with 7.5 mg phenobarbital/100 gm body weight for 15 days. 5IU FSH or FSH+LH per 100 gm body weight was administered from day 13 to 15 to the hemispayed phenobarbital treated rats. Phenobarbital inhibits the ovarian compensatory hypertrophy significantly and increases the cholesterol and lipid levels in the ovary. Administration of FSH a...

Circulating levels of gonadotrophins in immature mice treated neonatally with antisera to gonadotrophins.

Treatment of immature mice with gonadotrophins. Effects on some enzymic activities of unfractionated ovarian homogenates.

Treatment of immature mice with both follicle-stimulating hormone and human chorionic gonadotrophin in vivo resulted in large increases in the specific activities of ovarian alkaline phosphatase and alkaline nucleotidase. The specific activities of other ovarian enzymes studied were not altered by gonadotrophin treatment. A simultaneous change in the Michaelis constant of ovarian alkaline phosp...

Impact of ovarian stimulation with gonadotrophins on embryo aneuploidy.

Sir, We have read the article published in your journal by Taylor et al. (2014) with much interest. In this review the authors properly summarize the mechanisms, origins and incidence of chromosomal mosaicism in humans. The review is rigorous, exhaustive and very well-documented, and therefore we congratulate the authors for their work. Nevertheless, we find that some relevant information about...

Coasting (withholding gonadotrophins) for preventing ovarian hyperstimulation syndrome.

BACKGROUND Ovarian hyperstimulation syndrome (OHSS) is an iatrogenic and potentially life threatening condition resulting from excessive ovarian stimulation. Reported incidence varies from 1% to 10% of in vitro fertilization (IVF) cycles. The factors contributing to OHSS have not been completely explained. The release of vasoactive substances secreted by the ovaries under human chorionic gonado...